Clinical Question: As compared to placebo, does the angiotensin-II-receptor agonist (ARB) losartan delay progression to ESRD and improve mortality in patients with type 2 diabetes and nephropathy?
CURB-65: the easy-to-use clinical prediction rule helps us triage patients with pneumonia to inpatient or outpatient care. What is this actually based upon? This is the original study used to develop the CURB-65. Here are some things to think about…
This is the landmark trial that compares a restrictive to a liberal red blood cell transfusion strategy. Here are some things to think about when reading this article: What are our current pRBC transfusion goals for most patients? How are…
Rate control over rhythm control - that's the fundamental principle in treatment of atrial fibrillation, and here's the why we do this. Read the landmark article below and as a group, review the presentation here on TrialGuru.org.
Antiplatelet therapy is the cornerstone of secondary prevention of Stroke and TIA. But in contrast to acute coronary syndrome where patients get one year of aspirin plus clopidogrel, is there evidence of benefit for combination therapy after stroke/TIA? This article…
Methotrexate is the most common choice for disease-modifying anti-rheumatic drug (DMARD) for rheumatoid arthritis. This prospective study assesses the effect of methotrexate on mortality in a cohort of patients with rheumatoid arthritis. Some questions to consider while reviewing this article:…
The optimal duration of antibiotic treatment for ventilator-associated pneumonia (VAP) is not known. Shortening the course of therapy may help decrease antibiotic resistance and adverse effects of giving prolonged antibiotics. This study looks to establish that mortality and recurrent infections…
Anemia is a common complication of chronic kidney disease which is typically treated with recombinant human erythropoietin. However the ideal goal hemoglobin is not well established. This study looks to answer if a lower-goal hemoglobin CKD patients shows decreased adverse…
Sepsis continues to affect 1.5 million people and lead to 250,000 deaths in the U.S., according to the CDC. The CORTICUS study reviewed here (article below) is the landmark study evaluating the potential benefit of corticosteroids in septic patients. As…