First Wednesday: Altered Mental Status
Night Float Curriculum
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Fluoxetine for Motor Recovery After Acute Ischaemic Stroke (FLAME): A Randomised Placebo-controlled Trial
EBM, Journal Club
Clinical Question: Can adding fluoxetine to standard therapy for ischemic stroke improve recovery from motor deficits?
Neuropsychiatric Lupus
Morning Report
Excellent morning report today with Thomas Vu on Neuropsychiatric Lupus! Take a look at on the latest review on neuropsychiatric SLE: Management of Neuropsychiatric Systemic Lupus Erythematosus: Current Approaches and Future Perspectives on PubMed
Disseminated Histoplasmosis
Morning Report
Thank you Dr. Brendan Cerk for an excellent presentation on neurocysticercosis presenting with new onset seizure
Teaching Points
- Histoplasmosis is a common endemic mycosis, usually asymptomatic but occasionally results in severe illness
- Hematogenous dissemination occurs during the acute infection before cellular immunity develops
- Diagnosis: serum and urine antigen
- Treatment: itraconazole for 12 months, if CNS then liposomal amphotericin B for 4-6 weeks then itrazonazole for an additional 12 months
Neurocysticercosis
Morning Report
Thank you Dr. Rajat Suri for an excellent presentation on neurocysticercosis presenting with new onset seizure
Teaching Points
- Initial treatment for seizure: IV lorazepam 0.1mg/kg –> IV fosphenytoin –> sedation/intubation
- Neurocysticercosis is caused by Taenia Solium
- Spreads hematogenously to the brain, liver, muscle
- Diagnosis: presentation+imaging. serum testing not reliable
- Treatment: dexamethasone, albendazole, anti-epileptic