Thank you Dr. Kristina Lee for an excellent presentation on GIST
Teaching Points
- Important considerations in GI bleed: sx of volume depletion (dizzyness, syncope), hemodynamic instability or vitals differing from baseline, coagulopathy or other comorbid conditions
- Management of GI bleed
- fluids, goal hg>7, plt >50, INR<1.5.
- protonix drip if UGIB, add octreotide drip if concern for variceal bleed
- GIST sx: vague, nonspecific abdominal pain or discomfort, malaise, fatigue
- GIST dx: CT abdomen, PET, biopsy with path showing expression of the CD117 antigen
- GIST tx: surgery, tyrosine kinase inhibitors (imatinib)
Power Point: Morning Report 9-20-16
Further Reading:
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors Gastrointestinal stromaltumors – definition, clinical, histological, immunohistochemical and molecular genetic features and differential diagnosis