Thanks to Dr. John Hollowed and Dr. Rohit Godbole for an excellent morning report on APML

Learning Points:
— APML is linked with the t(15;17) translocation involving the RARa gene on chromosome 17 and the Promyelocytic Leukemia (PML) gene on chromosome 15
— APML is associated with DIC and patients are at high risk for intracranial bleeds
— Early recognition is KEY!
— Treatment includes all-trans retinoic acid +/- Aresenic or Anthracycline-based chemotherapy

Enjoy this great review article by Dr. Wang who discovered all-trans retinoic acid for APML