May 2017 - UCLA-Olive View Internal Medicine

May 19 2017

Acute Promyelocytic Leukemia

Morning Report

Thank you Dr. John Hollowed for an excellent presentation on acute promyelocytic leukemia

Teaching Points

APL accounts for 5-20% of AML cases
Increased incidence in people with prior cytotoxic therapy
Presents with complications of pancytopenia, weakness, fatigue, infections, increased bruising/bleeding, DIC
Diagnosis: bone marrow analysis and confirmation with PCR, FISH, or cytogenic analysis
Treatment is All-trans Retinoic Acid (ATRA)

May 15 2017

Morning Report

Presented by Dr. Liza Buchbinder

Moderated by Chief Resident

Thank you Dr. Liza Buchbinder for an excellent presentation on Huntington’s Disease

Teaching Points

Etiology: Autosomal dominant; Drug induced (antipsychotics, estrogen containing); Endocrine (thyrotoxicosis, hyperglycemia); pregnancy (chorea gravidarum); streptococcal infection (Sydenham chorea); autoimmune (SLE, APLS); neurodegenerative d/o of basal ganglia.
Associated w/ parkinsonism, impulsiveness, psychiatric disorders, and dementia.
Treatment is symptomatic