Archive of Didactics

Teaching Points: Definition: Episodic orbital pain associated with paralysis of one or more of the CN III, IV, VI due to granulomatous inflammation of the cavernous sinus Presents with episodic painful ophthalmoplegia, CNIII, IV, VI Palsy leading to diplopia, usually…

Teaching Points

• Potentially life-threatening, drug-induced hypersensitivity reaction
• Presents with fever, malaise, skin eruption, hematologic abnormalities (eosinophilia, atypical lymphocytosis), lymphadenopathy, and internal organ involvement (liver, kidney, lung)
• Management is withdrawal of offending drug, topical or oral/IV glucocorticoids (if severe disease)