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Jaundice And Transaminases >1000
Aug 17 2017

Jaundice and Transaminases >1000

Presented by Shirley Hu, M.D.

Moderated by Vinhfield Ta, M.D.

Thank you Shirley for a great presentation on a young patient presenting with jaundice, AST 2552 and ALT >5000!

What’s the differential?

Here’s a quick differential diagnosis for transaminases >1000:

  • Viral hepatitis
  • Drug/Toxin-induced liver injury
  • Autoimmune hepatitis
  • Ischemic/Shock liver
  • Budd-Chiari syndrome

It’s a narrow differential, so work it up with a good history and serologies.

In this case, Hepatitis B surface antigen and Hepatitis B core IgM antibody returned positive. The patient just needed supportive care and follow-up to ensure resolution of the acute hepatitis and viremia.


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